National Science and Technology Strategy Act of 2021 This bill requires the Office of Science and Technology Policy (OSTP) to develop a national science and technology strategy and publish a science and technology review. The bill revises OSTP reporting requirements to direct the OSTP to submit to Congress a comprehensive national science and technology strategy of the United States to meet national research and development objectives for the following four-year period. No later than December 31, 2022, and every four years afterwards, the OSTP shall complete a review of the science and technology enterprise of the United States.