San Francisco Bay Restoration Act of 2021 This bill provides support for the protection and restoration of the San Francisco Bay estuary and the recovery of certain species in the estuary. Specifically, it establishes a San Francisco Bay Program Office in the Environmental Protection Agency. The program must annually compile a list of funding priorities for projects or studies that advance the goals and objectives of the comprehensive conservation and management plan approved under the National Estuary Program for the San Francisco Bay estuary. The list must include projects or studies for water quality improvement; wetland, riverine, and estuary restoration and protection; nearshore and endangered species recovery; and adaptation to climate change. The program must review such plan at least once every five years and revise the plan as appropriate. The program may provide funding through grants or other means for studies or projects on the priority list.