COVID-19 and Pandemic Response Centers of Excellence Act of 2021 This bill establishes and provides funding for the COVID-19 and Pandemic Response Centers of Excellence Program Fund. The Department of Health and Human Services (HHS) must use the funds to set up at least 10 centers of excellence at academic medical centers to address issues associated with COVID-19 and future pandemic preparedness and response efforts. In addition, HHS must establish an advisory committee comprised of representatives from relevant federal agencies, each center of excellence, and national organizations that work with populations disproportionately impacted by COVID-19 and other health disparities. The committee must facilitate collaboration, information-sharing, and dissemination of best practices relating to COVID-19 and future pandemic responses.