This bill proposes to amend the 21st Century Cures Act , specifically targeting the grant program designed for State and Tribal Response to Opioid Use Disorders. The primary goal is to explicitly authorize the use of these federal funds for certain harm reduction tools. Currently, the grants can support drugs or devices legally marketed under the Federal Food, Drug, and Cosmetic Act. The proposed amendment would add fentanyl and xylazine test strips to the list of eligible items. This change aims to enhance substance use disorder and overdose prevention activities by ensuring that these critical test strips can be purchased with federal grant money.