The Mississippi River Restoration and Resilience Initiative Act, or MRRRI Act, aims to establish a nonregulatory initiative to protect and restore the ecological health and resilience of the Mississippi River for current and future generations, as well as for its fish and wildlife. This initiative will build upon existing efforts by providing funding for projects and activities across the Mississippi River Corridor. A key component is the establishment of the Mississippi River National Program Office within the Environmental Protection Agency (EPA) to lead these efforts. The MRRRI Director, appointed by the EPA Administrator, will coordinate Agency actions, develop and update actionable goals and an action plan, and ensure public access to information. The Director is also responsible for facilitating engagement and consultation with Tribal governments and organizations , including appointing a dedicated Tribal Liaison. An annual report detailing progress, coordination, and funded projects will be submitted to Congress and made publicly available. Projects carried out under the MRRRI must address at least one of six focus areas. These include improving water quality and drinking water, enhancing community resilience by restoring floodplains and wetlands, and protecting and restoring fish and wildlife habitat. Other focus areas involve preventing the spread of aquatic invasive species, improving communication and partnerships, and collecting scientific data to assess these areas. Funds can be used to implement eligible projects by federal agencies or non-federal entities, with the MRRRI Director authorized to make grants or enter agreements. Eligible projects encompass actions like restoring natural hydrologic functions, removing structures to restore river processes, permanently protecting private lands, reducing nonpoint source pollution, and controlling invasive species. The Federal share for most projects is 80%, but it is 100% for projects carried out by Tribal governments or organizations and for community capacity-building initiatives. The Act mandates the development of measurable actionable goals and a comprehensive action plan within two years, with updates every five years, through extensive stakeholder consultation. Additionally, it establishes a network of three Mississippi River Corridor Research Centers within the U.S. Geological Survey to conduct scientific research and advise on monitoring and project impacts. A science plan, informed by a Mississippi River science forum, will also be developed to establish priorities and research proposals for the MRRRI.