This bill amends the Federal Food, Drug, and Cosmetic Act to establish a new requirement for the Office of Food Chemical Safety, Dietary Supplements, and Innovation. Beginning in 2026, the Office must systematically and continuously reassess the safety of at least 10 food chemicals or classes of chemicals every three years. These reassessments will cover a broad range of substances, including food additives , color additives , substances generally recognized as safe (GRAS) , prior-sanctioned substances, and food contact substances. The Secretary is directed to prioritize substances for reassessment based on public health need and may select specific chemicals like titanium dioxide or various food dyes for initial review. Upon completion of each reassessment, the Secretary must provide public notice of the determinations. If a substance is found to be unsafe, the bill mandates specific regulatory actions, such as amending or repealing existing regulations, revoking prior sanctions, or deeming pre-market notifications ineffective. For GRAS substances, the FDA must publicly state whether the substance is safe under specified conditions or unsafe. Additionally, the bill requires the re-establishment of a Food Advisory Committee within 180 days to provide guidance on the standards and methods for these crucial safety reassessments.