The Muhammad Ali American Boxing Revival Act aims to significantly enhance the well-being of professional boxers and expand their opportunities by establishing requirements for "unified boxing organizations" (UBOs). These UBOs are private sector entities that organize professional boxing matches, implement their own title and ranking systems, and operate under unified rules without relying on independent sanctioning bodies. By meeting the bill's conditions, UBOs can offer an alternative system for boxers, providing increased choice in their careers.

The bill introduces stringent medical and safety standards for UBOs. This includes mandatory annual medical examinations for all contracted boxers, encompassing physicals, eye exams, HIV, and hepatitis tests. Female boxers must undergo pregnancy tests before each match, and all boxers require MRI and MRA brain scans every three years, with more frequent testing after knockouts, paid for by the UBO. Boxers aged 40 and older face additional annual supplemental medical examinations, including chest X-rays and EKGs.

For covered matches, UBOs must provide enhanced medical care, including two additional ambulances exclusively for boxers and three extra licensed physicians at ringside, with the UBO bearing these costs. Furthermore, UBOs are required to offer support services to contracted boxers, such as access to training and rehabilitation facilities, and an insurance policy covering training injuries, with the UBO responsible for premiums. Each boxer must also be assigned a medical coordinator to assist with licensing and medical requirements.

A comprehensive anti-doping program is mandated, featuring in-competition testing for at least half of participating boxers and no-notice testing, all conducted by independent third parties at the UBO's expense. The bill also requires UBOs to implement a strict boxing conduct policy, prohibiting boxers and "covered individuals" (including coaches, managers, and UBO staff) from betting on matches or sharing non-public information for wagering purposes. These policies aim to uphold the integrity of the sport.

To protect boxers financially, the bill prohibits UBOs from having financial interests in boxer management or charging fees for ranking or participation in championship matches, excluding reasonable expense reimbursements. It also establishes a minimum payment of $150 per round for each boxer in a match. UBOs must file organizational information with the Federal Trade Commission and the Association of Boxing Commissions, or make it publicly available online, ensuring transparency and accountability.