This bill, titled the "No More Missing Children Act," establishes the Unaccompanied Alien Child Anti-Trafficking Program under the Secretary of Health and Human Services, in coordination with the Secretary of Homeland Security. The program's primary goal is to prevent the trafficking, disappearance, or loss of unaccompanied alien children (UACs). All UACs released from custody on or after the bill's enactment, as well as those released before but still in the U.S., will be enrolled until they are removed, turn 18, or obtain lawful status.

The program mandates several stringent requirements for UACs and their sponsors. These include continuous GPS monitoring for both the child and sponsor, and monthly telephonic reporting for children aged four and older. Additionally, the Secretary must collect DNA from each UAC, their sponsor, and all adult household members, using DNA testing to confirm biological relationships when asserted.

A critical component of the program involves extensive vetting of sponsors before a child's release. This vetting process includes biometric information collection, an in-person interview, public records checks, FBI and interagency background checks, child abuse and neglect checks, and checks against various criminal and terrorism databases. Sponsors are deemed ineligible if they or an adult household member are unlawfully present (with exceptions), associated with criminal or terrorist organizations, registered sex offenders, or have certain criminal convictions or pending charges.

Furthermore, the Secretary is required to conduct a pre-placement home visit and inspection, followed by a minimum of six unannounced, in-person visits during the first year of placement, and four annually thereafter. If a sponsor fails to ensure the UAC complies with release conditions, such as attending court proceedings, the Secretary must terminate the placement, take custody of the child, and prohibit the sponsor from sponsoring any future UACs.