The Quantum Leadership in Emerging Applications and Policy Act of 2025, or the Quantum LEAP Act of 2025, establishes an independent Commission on American Quantum Information Science and Technology Dominance. This Commission, situated within the legislative branch, is tasked with examining and making recommendations regarding emerging quantum information science as it relates to the current and future missions of the U.S. Government and the private sector. It aims to ensure the United States maintains a leading edge in this critical technological domain. The Commission will comprise 12 members, including both Members of Congress and non-congressional experts. Appointments will be made by leadership from the Senate Commerce, Science, and Transportation Committee and the House Science, Space, and Technology Committee, as well as the majority and minority leaders of both chambers. Non-congressional members must be recognized experts with relevant professional experience in diverse quantum modalities, their use by policymakers and business leaders, or the implementation of national and economic security policies. A primary duty of the Commission is to conduct a comprehensive review of advances in quantum information science and associated technologies. This review will consider methods and investments necessary for the United States to secure and advance its development in this field, addressing national and economic security needs. The scope includes global competitiveness, national security advantages, international trends, fostering research and development, commercialization barriers, workforce development, international standards, and data sharing capabilities. The Commission is required to submit an interim report to Congress and the President within one year of its establishment, followed by a final report with findings and recommendations within two years. It will coordinate with relevant federal agencies like the Departments of Commerce and Energy, NIST, and NSF, and receive cooperation and support from federal departments. The Commission is authorized to hire staff, procure expert services, and accept non-monetary gifts to facilitate its work, and it will terminate 540 days after submitting its final report.