The "Promoting Resources to Expand Vaccination, Education and New Treatments for HPV Cancers Act of 2025," or the PREVENT HPV Cancers Act of 2025, seeks to amend the Public Health Service Act to establish a national public awareness campaign regarding human papillomavirus (HPV).

This campaign, to be carried out by the Secretary of Health and Human Services through the Director of the Centers for Disease Control and Prevention, aims to increase awareness of HPV vaccination's importance in preventing associated cancers, combat misinformation, and ultimately boost HPV vaccination rates and completion of the vaccine series.

The Secretary is required to consult with various stakeholders, including the National Academy of Medicine, healthcare providers, public health associations, and nonprofit organizations, to gather advice on evidence-based information for the campaign's development and implementation. The campaign will utilize evidence-based media and public engagement, awarding competitive grants or cooperative agreements to experienced nonprofit entities.

A key component involves developing culturally and linguistically competent resources tailored for communities with high rates of unvaccinated individuals, those disproportionately affected by HPV-associated cancers (such as Black and Hispanic women), rural communities, and populations impacted by oropharynx cancers, including active-duty service members and veterans.

Information dissemination will target healthcare providers, facilities, schools, and public health departments. The campaign must also be complementary to existing federal efforts on HPV vaccination and cancer screening, include message testing for behavioral change, and provide grants to State, local, and Tribal public health departments to engage communities and disseminate resources.

Additionally, the bill reauthorizes the Breast and Cervical Cancer Early Detection Program, increasing its authorized appropriation to $300,000,000 for each fiscal year from 2026 through 2030. The HPV cancer prevention public awareness campaign is authorized to receive $5,000,000 annually for fiscal years 2026 through 2030, and a report to Congress on its qualitative assessment and impact is required by September 30, 2027.