This legislation, titled the "Drunk Driving Prevention and Enforcement Act of 2025," aims to significantly reduce alcohol and drug-impaired driving fatalities and injuries through several key initiatives. It directs the Secretary of Transportation, through the National Highway Traffic Safety Administration (NHTSA), to establish a competitive prize program. This program will award a cash prize of not less than $45,000,000 to an entity that demonstrates consumer-ready, passive, advanced anti-drunk driving technology suitable for integration into passenger motor vehicles, with $50,000,000 authorized for the program. The bill also mandates the establishment of a Traffic Safety Enforcement Center of Excellence within the Department of Transportation within one year. This center will provide leadership and technical assistance to states and law enforcement agencies, focusing on maximizing efficient and effective traffic safety enforcement of hazardous driving behaviors. Its duties include promoting evidence-based strategies, developing best-practice protocols, delivering standardized training, and assisting agencies with data-driven enforcement, with $5,000,000 authorized annually for its operation. Furthermore, the legislation requires the NHTSA Administrator to establish a national drug involved crash data collection system . This system will collect standardized toxicology data from states for fatal and serious injury crashes, link various medical and crash records, and provide model protocols for specimen collection and testing. The Administrator may award grants to states for toxicology labs, training, and data systems, prioritizing high-fatality, rural, or underserved areas, with $30,000,000 authorized annually from fiscal years 2026 through 2031.